Sleep and glucose tolerance

{"cards":[{"_id":"77ed8ef6422425be23000029","treeId":"77ed8d4e422425be23000026","seq":9819352,"position":1,"parentId":null,"content":"Sleep and Glucose Tolerance"},{"_id":"77ed8f61422425be2300002a","treeId":"77ed8d4e422425be23000026","seq":9819353,"position":1,"parentId":"77ed8ef6422425be23000029","content":"Introduction\n"},{"_id":"77ed8fa5422425be2300002b","treeId":"77ed8d4e422425be23000026","seq":9819354,"position":2,"parentId":"77ed8ef6422425be23000029","content":"Epidemiology"},{"_id":"77edbd40422425be23000039","treeId":"77ed8d4e422425be23000026","seq":9819486,"position":2.5,"parentId":"77ed8ef6422425be23000029","content":"Sleep? General introduction?"},{"_id":"77ed8fcd422425be2300002c","treeId":"77ed8d4e422425be23000026","seq":9819355,"position":3,"parentId":"77ed8ef6422425be23000029","content":"Hormonal Changes\n"},{"_id":"77ed9c6d422425be23000033","treeId":"77ed8d4e422425be23000026","seq":9819368,"position":1,"parentId":"77ed8fcd422425be2300002c","content":"Increase in cortisol and growth hormone"},{"_id":"77ed9cba422425be23000034","treeId":"77ed8d4e422425be23000026","seq":9819369,"position":1,"parentId":"77ed9c6d422425be23000033","content":"Cortisol"},{"_id":"77ed9cd1422425be23000035","treeId":"77ed8d4e422425be23000026","seq":9819373,"position":1,"parentId":"77ed9cba422425be23000034","content":""},{"_id":"77ed9126422425be2300002d","treeId":"77ed8d4e422425be23000026","seq":9819356,"position":4,"parentId":"77ed8ef6422425be23000029","content":"Sympathetic Changes"},{"_id":"77ed9f2e422425be23000036","treeId":"77ed8d4e422425be23000026","seq":9819374,"position":1,"parentId":"77ed9126422425be2300002d","content":"a role of sympathetic activation—which negatively affects insulin secretion and sensitivity (71,72)—in response to sleep deprivation and fragmentation, reflected in an increase in blood pressure, lower heart rate variability and decreased baroreflex sensitivity (58,73). Some studies also reported increased catecholamine concentration following sleep deprivation (56,57,69). "},{"_id":"77ed9f65422425be23000037","treeId":"77ed8d4e422425be23000026","seq":9819402,"position":1,"parentId":"77ed9f2e422425be23000036","content":"How is this indicated?\n- Increased blood pressure\n- lower heart variability (increased vagal inhibition by sympathetic) \n- decreased baroreflex sensitivity\nAlso increased [catecholamine] in urine and plasma"},{"_id":"77edeb44422425be2300003c","treeId":"77ed8d4e422425be23000026","seq":9819612,"position":1.5,"parentId":"77ed9126422425be2300002d","content":"Activation of Alpha adrenoceptors on beta cells inhibits secretion by decreasing"},{"_id":"77ede459422425be2300003a","treeId":"77ed8d4e422425be23000026","seq":9819548,"position":2,"parentId":"77ed9126422425be2300002d","content":"Effect due to deficit in slow wave sleep?\nPaper by Tasali et al showing that slow wave sleep inhibition without disrupting sleep continuity"},{"_id":"77ede85b422425be2300003b","treeId":"77ed8d4e422425be23000026","seq":9819550,"position":1,"parentId":"77ede459422425be2300003a","content":"Sympathetic dominance again indicated through reduced heart rate variability"},{"_id":"77ed9174422425be2300002e","treeId":"77ed8d4e422425be23000026","seq":9819357,"position":5,"parentId":"77ed8ef6422425be23000029","content":"Circadian effects"},{"_id":"77ed91c0422425be2300002f","treeId":"77ed8d4e422425be23000026","seq":9819358,"position":1,"parentId":"77ed9174422425be2300002e","content":"Marcheva and effect of circadian disruption on the pancreas"},{"_id":"77ed931f422425be23000030","treeId":"77ed8d4e422425be23000026","seq":9819361,"position":1,"parentId":"77ed91c0422425be2300002f","content":"- Reduced insulin content in islet\n- Reduced ability to release insulin\n- Reduced size of islets"},{"_id":"77ed94f2422425be23000031","treeId":"77ed8d4e422425be23000026","seq":9819362,"position":2,"parentId":"77ed9174422425be2300002e","content":"Effect of sleep disruption of molecular circadian clock"},{"_id":"77ed9576422425be23000032","treeId":"77ed8d4e422425be23000026","seq":9819363,"position":1,"parentId":"77ed94f2422425be23000031","content":"Clock and Bmal1"},{"_id":"77edb81b422425be23000038","treeId":"77ed8d4e422425be23000026","seq":9819485,"position":3,"parentId":"77ed9174422425be2300002e","content":"Short Wave Sleep?\n\nSuppression of slow wave sleep without changing sleep time\ndecreased insulin sensitivity without compensation\nreduced glucose tolerance and increased risk of diabetes\nMagnitue of decrease in insulin sensitivty correlated to reduction in SWS\n"}],"tree":{"_id":"77ed8d4e422425be23000026","name":"Sleep and glucose tolerance","publicUrl":"sleep-and-glucose-tolerance"}}