• Sleep and Glucose Tolerance

  • Introduction

  • Epidemiology

  • Sleep? General introduction?

  • Hormonal Changes

  • Sympathetic Changes

  • Circadian effects

  • Increase in cortisol and growth hormone

  • a role of sympathetic activation—which negatively affects insulin secretion and sensitivity (71,72)—in response to sleep deprivation and fragmentation, reflected in an increase in blood pressure, lower heart rate variability and decreased baroreflex sensitivity (58,73). Some studies also reported increased catecholamine concentration following sleep deprivation (56,57,69).

  • Activation of Alpha adrenoceptors on beta cells inhibits secretion by decreasing

  • Effect due to deficit in slow wave sleep?
    Paper by Tasali et al showing that slow wave sleep inhibition without disrupting sleep continuity

  • Marcheva and effect of circadian disruption on the pancreas

  • Effect of sleep disruption of molecular circadian clock

  • Short Wave Sleep?

    Suppression of slow wave sleep without changing sleep time
    decreased insulin sensitivity without compensation
    reduced glucose tolerance and increased risk of diabetes
    Magnitue of decrease in insulin sensitivty correlated to reduction in SWS

  • Cortisol

  • How is this indicated?

    • Increased blood pressure
    • lower heart variability (increased vagal inhibition by sympathetic)
    • decreased baroreflex sensitivity
      Also increased [catecholamine] in urine and plasma
  • Sympathetic dominance again indicated through reduced heart rate variability

    • Reduced insulin content in islet
    • Reduced ability to release insulin
    • Reduced size of islets
  • Clock and Bmal1

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